Sustained HIV release by single persisting CD4 + T cells during latency disruption

HIV Can Establish Latency by Direct Infection of Resting CD4+ T Cells

HIV establishes a latent reservoir in a small pool of resting CD4+ T cells early in the infection of a new host. This viral reservoir has a very slow rate of decay and it is resistant to anti-retroviral therapy and the immune surveillance. This reservoir poses a significant obstacle to the eradication of virus in an infected individual. It is thus of importance to understand how this reservoir ...

Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells.

BACKGROUND Novel therapeutic approaches are needed to attack persistent proviral human immunodeficiency type 1 (HIV-1) infection. Hexamethylbisacetamide (HMBA), a hybrid bipolar compound, induces expression of the HIV-1 promoter in the long terminal repeat (LTR) region in a Tat-independent manner but mimics the effect of Tat, overcoming barriers to LTR expression and increasing the processivity...

Numerical solution of a fractional order model of HIV infection of CD4+T cells.

In this paper we consider a fractional order model of HIV infection of  CD4+T cells and we transform this fractional order system of ordinary differential equations to a system of weakly singular integral equations. Afterwards we propose a Nystrom method for solving resulting system, convergence result and order of convergence is obtained by using conditions of existence and uniqueness of solut...

Correction: Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4+ T Cells

Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells

Latently infected resting CD4(+) T cells are a major barrier to HIV cure. Understanding how latency is established, maintained and reversed is critical to identifying novel strategies to eliminate latently infected cells. We demonstrate here that co-culture of resting CD4(+) T cells and syngeneic myeloid dendritic cells (mDC) can dramatically increase the frequency of HIV DNA integration and la...